… [3]; interferon gamma receptor 1 and 2 mutations and mycobacterial and salmonella infections
[4]; interleukin 12 (IL-12) and IL-12 … in ligands, including mutations in IL-12 p40, leading to …

… STAT-1-independent or ISGF3-dependent. This novel disorder proves that IL12-induced,
IFN-γ-mediated immunity … Expression of IFN-γR or IL-12R does not imply function, and therefore …

… for IL-12 production and for protective immunity against … of IFN-γ because of a lack of stimulation
through the IL-12R. This … The patients with AR complete STAT-1 deficiency had multiple, …

… of a novel primary immunodeficiency syndrome, subsequently … IFN-γR1 and IL-12R*1
deficiency, indicating that IL-12 and … either STAT-1 independent or ISGF3 dependent. This novel …

… IL-12 and IL-23; IRF8, a transcription factor inducible by IFN-γ… , an IFN-γ-inducing molecule
that acts in synergy with IL-12; … immunodeficiencies (PID) underlie mycobacterial diseases, …

… of the IL-12-IFN-γ pathway was successful in identifying immune deficits … to the
Interleukin-12-Interferongamma (IL-12-IFN-γ) pathway, … Signal transduction through IL-12R firstly …

… ) e expressar os receptores de IL-12 (IL-12R) e IFN-γ. Além … as follows the primary
immunodeficiency disorders (PIDs) in … the cells were stained with anti pY701 STAT-1 antibody …

… The level of IFN- production is modulated by IL-12, by a … STAT-1 STAT-1 phosphorylation
is a defining feature of the … IL-12 binding to IL-12R leads to Tyk2 and JAK2 transactivation, …

… in limto enhance IL-12R 2 expression through STAT-1- … the importance of IL-12 and IFN- in
resistance production of IFN- , … parasite of prenatal infants and immunocompromised tion for …

… of STAT-1, which is a downstream molecule of the IL-12R in … role of the IFN-γ-CXCL9/CXCL10
axis in the effect of IL-12, but … In our experimental conditions, we observe that STAT-1 is …